Winter of Our Discontent

First Panel:
Calvin: I wonder why people are never content with what they have.
Second Panel:
Hobbes: Are you kidding? Your fingernails are a joke, you've got no fangs, you can't see at night, your pink hides are ridiculous, your reflexes are nil, and you don't even have tails! Of course people aren't content!
Third Panel:
Calvin: Forget I said anything.
Hobbes: Now if tigers weren't content. That would be something to wonder about.

Wikipedia link on Calvin and Hobbes- some good long reading.

Also off wikipedia- Horrendous Space Kablooie entry in full:

The Horrendous Space Kablooie is an alternate term for the Big Bang, coined by Bill Watterson in his comic strip Calvin and Hobbes.

In one strip, Calvin says to Hobbes, "I've been reading about the beginning of the universe. They call it 'The Big Bang.' Isn't it weird how scientists can imagine all the matter of the universe exploding out of a dot smaller than the head of a pin, but they can't come up with a more evocative name for it than 'the Big Bang'? That's the whole problem with science. You've got a bunch of empiricists trying to describe things of unimaginable wonder."

Hobbes asks, "What would you call the creation of the universe?"

Calvin replies, "The Horrendous Space Kablooie!"

This term enjoyed a brief popularity in the scientific community and was widely used in informal communications (often abbreviated to "the HSK").